I have a question regarding Strep Throat. If I am pregnant and have a sore throat, what medications are safe to take? Monday, July 23, When do the show animals arrive? Whenever a sore throat is severe, persists longer than the usual five to seven day duration of a "cold" or "flu" and is not associated with an avoidable allergy or irritation, you should seek medical attention. Although some of these signs and symptoms may be related to a strep throat infection, they can also be indicators of other emergent conditions such as peritonsillar abscess , epiglottitis , tracheitis, or retropharyngeal abscess.